Most multi-tool functions are straight forward. A knife cuts, a file grinds, and a can opener...well you get the idea. With years of use, we've come across some pretty cool tips.
Have a knot synched up too tight to undo? Use your needle-nosed pliers to grab part of the knot and work it undone. If you have 2 pairs of pliers it's that much easier. I never undo my kids double knots on their shoes with my fingers - out comes the Leatherman.
Cut zip ties with the wire cutter, NOT the blade. You have way more control with the cutters on the pliers because the zip ties are fairly rigid.